Urolithiasis is the presence of uroliths/calculi (stones) in the urinary tract. Amarathus viridis L is useful in treating urinary calculi. Hence the present study, made to establish the scientific validity for the antiurolithaitic activity of Amaranthus viridis L. Wistar rats divided into four groups containing six in each and kept in metabolic cages individually for entire duration of the experiment. All animals had free access to regular rat chow and drinking water ad libitum. Group I served as normal. Group II received ethylene glycol for 30 days. After administration of ethylene glycol for 15 days, group III received cystone, group IV were treated with aqueous extract of Amaranthus viridis. On 30th day of the experiment, animals were housed in metabolic cages and 24 hour urine samples and serum samples were collected. At the end all the animals were sacrificed. The urine and serum samples were used for estimation of biochemical parameters such as calcium, phosphorus, creatinine, uric acid were determined. Deposition of crystal is indicated by increased blood levels and decreased urinary levels of biochemical parameters such as creatinine, uric acid with a decrease in blood level of calcium and increase urinary levels of calcium. Administration of aqueous extract enhanced the excretion of biochemical parameters and decreases their concentration in blood. In conclusion, the data revealed were suggested that Amaranthus viridis L. possess significant antiurolithiatic activity.
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